Eltrombopag Olamine ( Eltrombopag diethanolamine salt; SB-497115GR )

Catalog No. M18653 CAS No. 496775-62-3

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Product Name

Eltrombopag Olamine
Note

Research use only, not for human use.
Brief Description

Eltrombopag Olamine is the orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity.
Description

Eltrombopag Olamine is the orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production.
Synonyms

Eltrombopag diethanolamine salt; SB-497115GR
Pathway

Others
Target

Other Targets
Recptor

Thrombopoietin receptor
Research Area

Cardiovascular Disease
Indication

——

CAS Number

496775-62-3
Formula Weight

564.63
Molecular Formula

C29H36N6O6
Purity

98%
Solubility

DMSO : ≥ 50 mg/mL; 88.55 mM
SMILES

Cc1c(cc(cc1)n1c(=O)c(c([nH]1)C)N/N=C/1\C=CC=C(C1=O)c1cc(ccc1)C(=O)O)C.C(CO)N.C(CO)N
Chemical Name

——

1. Erickson-Miller CL, et al. Stem Cells, 2009, 27(2), 424-430.

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